Enabling efficient, scalable Suzuki coupling with advanced palladium catalysts and scalable protocols
Suzuki coupling is a palladium-catalyzed cross-coupling reaction between organoboron compounds and halides, facilitating the formation of carbon-carbon bonds. This versatile reaction is essential for synthesizing complex organic molecules in pharmaceuticals, agrochemicals, and other specialty chemicals.
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Enables the synthesis of advanced APIs and intermediates, particularly for oncology and antiviral drugs.
Used to create active ingredients in herbicides, fungicides, and insecticides with improved efficiency.
Facilitates the development of advanced materials, including polymers and chemical precursors.
The Suzuki-Miyaura coupling reaction is a key step in the synthesis of Losartan, an angiotensin II receptor blocker (ARB) used to treat hypertension. This palladium-catalyzed cross-coupling reaction enables the formation of a biaryl bond, which is essential for the drug's pharmacological activity.
Aryl Halide Substrate: 2-Butyl-4-chloro-5-formylimidazole
Boron Reagent: 4-(Boronate)Biphenyl (Boronic acid derivative)
Catalyst: Palladium(0) complex (e.g., Pd(PPh₃)₄)
Base: Potassium carbonate (K₂CO₃) or Sodium hydroxide (NaOH)
Solvent: Tetrahydrofuran (THF) or Aqueous-organic system
Cyanation is a chemical process that introduces a cyano group (-CN) in...
Hydrogenation is a chemical process in which hydrogen (H2) is added to...
Biocatalysis harnesses the power of enzymes or microorganisms to catal...
Fluorination is a chemical process used to introduce one or more fluor...
From lab-scale testing to pilot-scale production to finished formulations and regulatory support, our CRO services are designed to streamline your journey to market with precision and expertise.
Our CMO services enable seamless production processes to meet your custom specifications and timelines, catering to both small-scale and large-scale production needs.
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Expertise in palladium catalyst optimization for high efficiency and yield
Specialized setups for large-scale cross-coupling reactions under controlled conditions
Comprehensive services and diverse tailored Suzuki coupling protocols for multiple industrial applications
Eco-friendly processes that minimize waste and enable catalyst recycling
👥 Speaker: Vilas Sahasrabuddhey
👤 Host: Hersh Manek - Business Head, Flavors & Fragrances, Scimplify
👤 Co-Host: Nikita Ghode - Senior Manager, Market Intelligence, Scimplify
👥 Speaker: Dr. T Pavan Kumar
👤 Host: Mr Karthik Kumar - Business Head, Pharmaceuticals, Scimplify
