Piroctone Olamine (CAS NO:68890-66-4)

It is widely used in personal care formulations, particularly in anti-dandruff shampoos, scalp treatments, and hair care products. It acts as an antifungal and antimicrobial agent. Functions as an antimicrobial compound that inhibits the growth of Malassezia species, effectively reducing dandruff and seborrheic dermatitis. It exhibits high bioavailability and low cytotoxicity in dermatological studies. Commonly found in anti-dandruff shampoos, helping to reduce itching, flaking, and irritation of the scalp.

Acts by disrupting the energy metabolism of fungal cells, particularly Malassezia, leading to their inhibition and death. It’s used as a synergistic ingredient with other actives like Zinc Pyrithione or Climbazole in premium hair care formulations. It interferes with iron metabolism in fungal cells, limiting cell growth. Its molecular structure allows better penetration into the scalp, providing targeted antifungal action.

Consumers: Piroctone Olamine works by eliminating dandruff-causing fungi, relieving itching, flaking, and scalp irritation, often delivering visible results within 2-4 weeks of regular use.

Approved for use in cosmetic products in the EU, Asia, and most regions. Typical concentrations range from 0.2% to 1.0%, depending on product claims. Formulators must comply with Cosmetic Directive 76/768/EEC and REACH standards. Research confirms low irritation potential and broad-spectrum antimicrobial activity, making it ideal for cosmetic dermatology applications. It complies with pharmacopoeial standards for active ingredients in topical formulations. Found in many over-the-counter and premium anti-dandruff shampoos, safe for frequent use, and often labeled as scalp-soothing or anti-itch.

Piroctone Olamine is non-toxic to aquatic life, offers better scalp tolerability, and supports natural formulations. It is often selected for premium anti-dandruff products where mildness and efficacy are required. It shows greater cell compatibility in vitro and lower cytotoxicity compared to Zinc Pyrithione. Its mechanism of action is selective, reducing side effects and promoting a healthier scalp microbiome. Many prefer shampoos with Piroctone Olamine for its gentle action, soothing feel, and reduced risk of dryness and irritation compared to traditional anti-dandruff ingredients.

It is an antifungal and antibacterial agent, mainly used in anti-dandruff shampoos and skincare formulations.

Yes, Piroctone Olamine is known for its low irritation profile, making it safer than zinc pyrithione in dermatological formulations.