Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Alternative chemical name is (±)-1-sec-Butyl-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ²-1,2,4-triazolin-5-one
Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Alternative chemical name is (±)-1-sec-Butyl-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ²-1,2,4-triazolin-5-one
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
Used to treat systemic and superficial fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis.
Effective in treating dermatophytoses and other cutaneous fungal infections
Itraconazole is an antifungal medication prescribed to treat various fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis.
Itraconazole is available in capsules, oral solutions, and intravenous forms. The capsules should be taken with a full meal to enhance absorption, while the oral solution is better absorbed on an empty stomach. Always follow your healthcare provider's instructions regarding dosage and administration.
Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. If you experience severe side effects such as signs of liver problems (e.g., yellowing of the skin or eyes), heart failure symptoms, or severe allergic reactions, seek medical attention promptly.
Yes, certain medications can interact with Itraconazole, leading to serious side effects. Drugs such as cisapride, pimozide, quinidine, and certain statins (e.g., lovastatin, simvastatin) should not be taken with Itraconazole. Inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
The safety of Itraconazole during pregnancy or breastfeeding is not well-established. It is essential to consult your healthcare provider to weigh the potential risks and benefits before using this medication in such situations.
Itraconazole should be stored at room temperature, away from moisture and heat. Keep the medication in its original container, tightly closed, and out of reach of children.
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