N,N'-Carbonyl diimidazole (CDI) is an organic reagent primarily used in peptide synthesis, protein modification, and pharmaceutical research. It serves as a coupling reagent in peptide bond formation, promoting the reaction between amines and carboxylic acids. CDI is widely used in chemical manufacturing, particularly in the creation of bioconjugates, owing to its efficiency in activating carboxyl groups. It also plays a crucial role in the synthesis of nucleic acid derivatives and other complex organic molecules
N,N'-Carbonyl diimidazole (CDI) is an organic reagent primarily used in peptide synthesis, protein modification, and pharmaceutical research. It serves as a coupling reagent in peptide bond formation, promoting the reaction between amines and carboxylic acids. CDI is widely used in chemical manufacturing, particularly in the creation of bioconjugates, owing to its efficiency in activating carboxyl groups. It also plays a crucial role in the synthesis of nucleic acid derivatives and other complex organic molecules
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Reagents
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Chemical Properties & Specifications
Used in peptide synthesis, especially for the coupling of amino acids in the formation of peptides and proteins.
Serves as a reagent in the synthesis of bioconjugates and nucleic acid derivatives.
Utilized in organic synthesis, particularly in modifying biomolecules for various chemical applications.
CDI is a widely used reagent in organic synthesis, particularly for peptide coupling, nucleoside activation, and esterification reactions. It is also employed in pharmaceutical and agrochemical industries.
CDI acts as a dehydrating agent, facilitating the formation of amide, ester, and carbamate bonds by activating carboxyl groups for nucleophilic attack.
CDI is highly reactive and should be handled with protective gloves and eyewear. It should be stored in a cool, dry place away from moisture and strong acids.
Yes, CDI is commonly used in large-scale synthesis of pharmaceuticals, agrochemicals, and specialty chemicals due to its efficiency in coupling reactions.
CDI is preferred due to its high reactivity, minimal side products, and compatibility with various solvents, making it an efficient and clean reagent for organic synthesis.
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