Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Itraconazole is also a member of the triazoles class, dioxolane, N-arylpiperazine, dichlorobenzene, cyclic ketal, and aromatic ether. Derived from cis-ketoconazole, its imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group, and the acetyl group on the piperazine moiety is substituted by a p-[(±)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. ECHA deprecated cas number is 84604-65-9.
Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Itraconazole is also a member of the triazoles class, dioxolane, N-arylpiperazine, dichlorobenzene, cyclic ketal, and aromatic ether. Derived from cis-ketoconazole, its imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group, and the acetyl group on the piperazine moiety is substituted by a p-[(±)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. ECHA deprecated cas number is 84604-65-9.
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Chemical Properties & Specifications
Used to treat systemic and superficial fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis.
Effective in treating dermatophytoses and other cutaneous fungal infections
Ensures prolonged circulation time and sustained therapeutic levels.
Available in multiple formulations to suit different treatment needs.
Aspergillosis, blastomycosis, histoplasmosis Oral treatments for systemic fungal infections Cosmetic formulations aimed at improving hair growth (in some formulations)
Onychomycosis
Systemic fungal infections
Aimed at improving hair growth (in some formulations)
Itraconazole is an antifungal medication used to treat a variety of fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis. It is also effective for fungal infections of the skin, nails, and internal organs.
Itraconazole is available in capsules, oral solutions, and intravenous forms. The capsules should be taken with a full meal to enhance absorption, while the oral solution is better absorbed on an empty stomach. Always follow your healthcare provider's instructions regarding dosage and administration.
Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. If you experience severe side effects such as liver problems (yellowing of skin or eyes), heart failure symptoms, or severe allergic reactions, seek medical attention promptly.
Yes, certain medications may interact with Itraconazole, leading to serious side effects. Medications like cisapride, pimozide, quinidine, and certain statins (e.g., lovastatin, simvastatin) should not be taken with Itraconazole. Always inform your healthcare provider of all medications and supplements you are using.
The safety of Itraconazole during pregnancy or breastfeeding is not well-established. It is essential to consult your healthcare provider to weigh the potential risks and benefits before using this medication in such situations.
Itraconazole should be stored at room temperature, away from moisture and heat. Keep the medication in its original container, tightly closed, and out of reach of children.
itraconazole, 84625-61-6, Oriconazole, Sporanox, Itrizole, Itrizole (TN), 873066-43-4, Sporanox (TN), ITCZ, Itraconazol, Fungitraxx, Itraconazolo, Itraconazolum, Sporonox, Cladosal 100, 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one, DTXSID3023180, Itraconazole (Sporanox), NSC-759239, Itraconazol [Spanish], Itraconazolum [Latin]
Itraconazole is manufactured globally, with key suppliers and manufacturers located in India, China, and several European countries. These regions are recognized for their large-scale pharmaceutical production capabilities and high-quality manufacturing standards. Leading suppliers in these regions adhere to (GMP), ensuring the consistent quality and regulatory compliance.
The assay specification for Itraconazole typically falls within the range of 98-102%, ensuring its potency and purity for pharmaceutical applications.
High-performance liquid chromatography (HPLC) is commonly used to test the purity and assay of Itraconazole, in line with pharmaceutical standards.
The minimum order quantity (MOQ) for Itraconazole may vary depending on the supplier, but it typically starts from 1 kg for bulk purchases.
Yes, pricing for Itraconazole can be customized based on order volume, frequency, and customer requirements, especially for long-term contracts or bulk orders.
Yes, formulation support is typically available for Itraconazole, particularly for topical formulations, oral solutions, and injectable forms.
Itraconazole is typically cGMP certified, and manufacturers may also hold certifications like USP, EP, and ISO for quality assurance and regulatory compliance.
Yes, documentation such as Certificates of Analysis (COA), GMP compliance certificates, and MSDS are available to confirm the product’s quality and regulatory compliance.
Yes, Itraconazole is available in both base and salt forms, depending on the intended formulation and application.
The preferred grade for Itraconazole export is typically USP grade or EP grade, which ensures compliance with international regulatory standards.
Yes, long-term supply contracts for Itraconazole can be arranged, particularly for pharmaceutical manufacturers, ensuring a steady supply for ongoing production needs.
India, North America, EU preferrably
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